解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Escherichia coli infections known as colibacillosis constitute a considerable challenge to poultry farmers worldwide, in terms of decreased animal welfare and production economy. Colibacillosis is caused by avian pathogenic E. coli (APEC). APEC strains are extraintestinal pathogenic E. coli and have in gener...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3415-6
更新日期:2017-01-03 00:00:00
abstract:BACKGROUND:Though glioblastoma multiforme (GBM) is the most frequently occurring brain malignancy in adults, clinical treatment still faces challenges due to poor prognoses and tumor relapses. Recently, microRNAs (miRNAs) have been extensively used with the aim of developing accurate molecular therapies, because of the...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3321-y
更新日期:2016-12-22 00:00:00
abstract:BACKGROUND:Simple sequence repeats (SSRs) have become widely used as molecular markers in plant genetic studies due to their abundance, high allelic variation at each locus and simplicity to analyze using conventional PCR amplification. To study plants with unknown genome sequence, SSR markers from Expressed Sequence T...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3328-4
更新日期:2016-12-22 00:00:00
abstract:BACKGROUND:Many gram-negative bacteria use type III secretion systems (T3SSs) to translocate effector proteins into host cells. T3SS effectors can give some bacteria a competitive edge over others within the same environment and can help bacteria to invade the host cells and allow them to multiply rapidly within the ho...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3363-1
更新日期:2016-12-19 00:00:00
abstract:BACKGROUND:Clock genes are considered to be the molecular core of biological clock in vertebrates and they are directly involved in the regulation of daily rhythms in vertebrate tissues such as skeletal muscles. Fish myotomes are composed of anatomically segregated fast and slow muscle fibers that possess different met...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3373-z
更新日期:2016-12-08 00:00:00
abstract:BACKGROUND:For their transmission, African trypanosomes rely on their blood feeding insect vector, the tsetse fly (Glossina sp.). The ingested Trypanosoma brucei parasites have to overcome a series of barriers in the tsetse fly alimentary tract to finally develop into the infective metacyclic forms in the salivary glan...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3283-0
更新日期:2016-11-25 00:00:00
abstract:BACKGROUND:The Xklp2 (TPX2) proteins belong to the microtubule-associated (MAP) family of proteins. All members of the family contain the conserved TPX2 motif, which can interact with microtubules, regulate microtubule dynamics or assist with different microtubule functions, for example, maintenance of cell morphology ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3303-0
更新日期:2016-11-24 00:00:00
abstract:BACKGROUND:Avian pathogenic Escherichia coli (APEC) causes colibacillosis, which results in significant economic losses to the poultry industry worldwide. However, the diversity between isolates remains poorly understood. Here, a total of 272 APEC isolates collected from the United Kingdom (UK), Italy and Germany were ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3289-7
更新日期:2016-11-22 00:00:00
abstract:BACKGROUND:Host genetics is one of several factors known to shape human gut microbiome composition, however, the physiological processes underlying the heritability are largely unknown. Inter-individual differences in host factors secreted into the gut lumen may lead to variation in microbiome composition. One such fac...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3290-1
更新日期:2016-11-21 00:00:00
abstract:BACKGROUND:In mammals, CEACAM1 and closely related members represent paired receptors with similar extracellular ligand-binding regions and cytoplasmic domains with opposing functions. Human CEACAM1 and CEACAM3 which have inhibitory ITIM/ITSM and activating ITAM-like motifs, respectively, in their cytoplasmic regions a...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3279-9
更新日期:2016-11-16 00:00:00
abstract:BACKGROUND:The bacterial CRISPR system is fast becoming the most popular genetic and epigenetic engineering tool due to its universal applicability and adaptability. The desire to deploy CRISPR-based methods in a large variety of species and contexts has created an urgent need for the development of easy, time- and cos...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3268-z
更新日期:2016-11-14 00:00:00
abstract:BACKGROUND:The TALLYHO/Jng (TH) mouse is a polygenic model for obesity and type 2 diabetes first described in the literature in 2001. The origin of the TH strain is an outbred colony of the Theiler Original strain and mice derived from this source were selectively bred for male hyperglycemia establishing an inbred stra...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3245-6
更新日期:2016-11-11 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) post-transcriptionally regulate a variety of genes involved in eukaryotic cell growth, development, metabolism and other biological processes, and numerous miRNAs are implicated in the initiation and progression of cancer. Enzootic nasal adenocarcinoma (ENA), an epithelial tumor induced in...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3238-5
更新日期:2016-11-08 00:00:00
abstract:BACKGROUND:The transcription factor SOX10 is essential for all stages of Schwann cell development including myelination. SOX10 cooperates with other transcription factors to activate the expression of key myelin genes in Schwann cells and is therefore a context-dependent, pro-myelination transcription factor. As such, ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3167-3
更新日期:2016-11-07 00:00:00
abstract:BACKGROUND:Massively-parallel sequencing at depth is now enabling tumor heterogeneity and evolution to be characterized in unprecedented detail. Tracking these changes in clonal architecture often provides insight into therapeutic response and resistance. In complex cases involving multiple timepoints, standard visuali...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3195-z
更新日期:2016-11-07 00:00:00
abstract:BACKGROUND:Crustaceans have been studied extensively as model systems for nervous system function from single neuron properties to behavior. However, lack of molecular sequence information and tools have slowed the adoption of these physiological systems as molecular model systems. In this study, we sequenced and perfo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3215-z
更新日期:2016-11-04 00:00:00
abstract:BACKGROUND:Gene duplication is prevalent in many species and can result in coding and regulatory divergence. Gene duplications can be classified as whole genome duplication (WGD), tandem and inserted (non-syntenic). In maize, WGD resulted in the subgenomes maize1 and maize2, of which maize1 is considered the dominant s...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3194-0
更新日期:2016-11-04 00:00:00
abstract:BACKGROUND:Volvox carteri (V. carteri) is a multicellular green alga used as model system for the evolution of multicellularity. So far, the contribution of small RNA pathways to these phenomena is not understood. Thus, we have sequenced V. carteri Argonaute 3 (VcAGO3)-associated small RNAs from different developmental...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3202-4
更新日期:2016-11-02 00:00:00
abstract:BACKGROUND:Sequencing data from The Cancer Genome Atlas (TGCA), the International Cancer Genome Consortium and other research institutes have revealed the presence of genetic alterations in several tumor types, including gastric cancer. These data have been combined into a catalog of significantly mutated genes for eac...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3166-4
更新日期:2016-10-26 00:00:00
abstract:BACKGROUND:Bacterial non-coding RNAs act by base-pairing as regulatory elements in crucial biological processes. We performed the identification of trans-encoded small RNAs (sRNA) from the genomes of Mycoplama hyopneumoniae, Mycoplasma flocculare and Mycoplasma hyorhinis, which are Mycoplasma species that have been ide...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3061-z
更新日期:2016-10-25 00:00:00
abstract:BACKGROUND:Preterm birth (PTB), birth at <37 weeks of gestation, is a significant global public health problem. World-wide, about 15 million babies are born preterm each year resulting in more than a million deaths of children. Preterm neonates are more prone to problems and need intensive care hospitalization. Health ...
journal_title:BMC genomics
pub_type: 杂志文章,评审
doi:10.1186/s12864-016-3089-0
更新日期:2016-10-17 00:00:00
abstract:BACKGROUND:Sugarcane smut, which is caused by Sporisorium scitamineum, has been threatening global sugarcane production. Breeding smut resistant sugarcane varieties has been proven to be the most effective method of controlling this particular disease. However, a lack of genome information of sugarcane has hindered the...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3146-8
更新日期:2016-10-12 00:00:00
abstract:BACKGROUND:Ras-related proteins in brain (Rab)-family proteins are key members of the membrane trafficking pathway in cells. In addition, these proteins have been identified to have diverse functions such as cross-talking with different kinases and playing a role in cellular signaling. However, only a few Rab proteins ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3145-9
更新日期:2016-10-10 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are short non-coding RNAs that are emerging as important post-transcriptional regulators of neuronal and synaptic development. The precise impact of miRNAs on presynaptic function and neurotransmission remains, however, poorly understood. RESULTS:Here, we identify miR-27b-an abundant neur...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3139-7
更新日期:2016-10-04 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression mainly through translational repression of target mRNA molecules. More than 2700 human miRNAs have been identified and some are known to be associated with disease phenotypes and to display tissue-specific patterns of expression. ME...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3114-3
更新日期:2016-10-04 00:00:00
abstract:BACKGROUND:A-to-I RNA-editing mediated by ADAR (adenosine deaminase acting on RNA) enzymes that converts adenosine to inosine in RNA sequence can generate mutations and alter gene regulation in metazoans. Previous studies have shown that A-to-I RNA-editing plays vital roles in mouse embryogenesis. However, the RNA-edit...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3115-2
更新日期:2016-09-29 00:00:00
abstract:BACKGROUND:Bayesian mixture models in which the effects of SNP are assumed to come from normal distributions with different variances are attractive for simultaneous genomic prediction and QTL mapping. These models are usually implemented with Monte Carlo Markov Chain (MCMC) sampling, which requires long compute times ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3082-7
更新日期:2016-09-21 00:00:00
abstract:BACKGROUND:Genome-wide association studies have revealed associations between single-nucleotide polymorphisms (SNPs) and phenotypes such as disease symptoms and drug tolerance. To address the small sample size for rare variants, association studies tend to group gene or pathway level variants and evaluate the effect on...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3094-3
更新日期:2016-09-21 00:00:00
abstract:BACKGROUND:Recent molecular studies have revealed considerably more diversity in the phylum Chlamydiae than was previously thought. Evidence is growing that many of these novel chlamydiae may be important pathogens in humans and animals. A significant barrier to characterising these novel chlamydiae is the requirement ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3055-x
更新日期:2016-09-05 00:00:00
abstract:BACKGROUND:Poxviruses constitute one of the largest and most complex animal virus families known. The notorious smallpox disease has been eradicated and the virus contained, but its simian sister, monkeypox is an emerging, untreatable infectious disease, killing 1 to 10 % of its human victims. In the case of poxviruses...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2826-8
更新日期:2016-08-31 00:00:00
abstract:BACKGROUND:Early maturity is one of the most important and complex agronomic traits in upland cotton (Gossypium hirsutum L). To dissect the genetic architecture of this agronomically important trait, a population consisting of 355 upland cotton germplasm accessions was genotyped using the specific-locus amplified fragm...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2875-z
更新日期:2016-08-30 00:00:00
abstract:BACKGROUND:Transcriptomics in non-model plant systems has recently reached a point where the examination of nuclear genome-wide patterns in understudied groups is an achievable reality. This progress is especially notable in evolutionary studies of ferns, for which molecular resources to date have been derived primaril...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3034-2
更新日期:2016-08-30 00:00:00
abstract:BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and destruction of synovial joints. RA affects up to 1 % of the population worldwide. Currently, there are no drugs that can cure RA or achieve sustained remission. The unknown cause of the disease represents a significan...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2910-0
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:Starch and protein are two major components of polished rice, and the amylose and protein contents affect eating and cooking qualities (ECQs). In the present study, genome-wide association study with high-quality re-sequencing data was performed for 10 ECQs in a panel of 227 non-glutinous rice accessions and...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3000-z
更新日期:2016-08-20 00:00:00
abstract:BACKGROUND:Cichlid fishes have evolved remarkably diverse reproductive, social, and feeding behaviors. Cell-to-cell signaling molecules, notably neuropeptides and peptide hormones, are known to regulate these behaviors across vertebrates. This class of signaling molecules derives from prohormone genes that have undergo...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2914-9
更新日期:2016-08-19 00:00:00
abstract:BACKGROUND:High throughput molecular sequencing and increased biospecimen variety have introduced significant informatics challenges for research biorepository infrastructures. We applied a modular system integration approach to develop an operational biorepository management system. This method enables aggregation of ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2797-9
更新日期:2016-08-18 00:00:00
abstract:BACKGROUND:Identification and classification of highly similar microbial strains is a challenging issue in microbiology, ecology and evolutionary biology. Among various available approaches, gene content analysis is also at the core of microbial taxonomy. However, no threshold has been determined for grouping microorgn...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2991-9
更新日期:2016-08-17 00:00:00
abstract:BACKGROUND:Host-specific environmental factors induce changes in Bacillus anthracis gene transcription during infection. A global transcription regulator, CodY, plays a pivotal role in regulating central metabolism, biosynthesis, and virulence in B. anthracis. In this study, we utilized RNA-sequencing to assess changes...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3004-8
更新日期:2016-08-17 00:00:00
abstract:BACKGROUND:An estimated 15,000 children and adolescents under the age of 19 years are diagnosed with leukemia, lymphoma and other tumors in the USA every year. All children and adolescent acute leukemia patients will undergo chemotherapy as part of their treatment regimen. Fortunately, survival rates for most pediatric...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2965-y
更新日期:2016-08-15 00:00:00
abstract:BACKGROUND:Extra-cellular components, such as serum and exosome, have drawn great attention as a readily accessible source of biomarkers for mammalian health. However, the contribution of different blood components to the signature of respective microRNAs (miRNAs) remains unknown, especially in cattle. In this study we...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2962-1
更新日期:2016-08-12 00:00:00